Single all-fiber-based nanosecond-pulsed supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography

by Xiao Shu*, Magalie Bondu*, Biqin Dong, Adrian Podoleanu, Lasse Leick, and Hao F. Zhang

Journal: Optics Letters 41 (12), 2743-2746 (2016)

Published: June 8, 2016

We report the usefulness of a single all-fiber-based supercontinuum (SC) source for combined photoacoustic microscopy (PAM) and optical coherence tomography (OCT). The SC light is generated by a tapered photonic crystal fiber pumped by a nanosecond pulsed master oscillator power amplifier at 1064 nm. The spectrum is split into a shorter wavelength band (500–800 nm) for single/multispectral PAM and a longer wavelength band (800–900 nm) band for OCT. In vivo mouse ear imaging was achieved with an integrated dual-modality system. We further demonstrated its potential for spectroscopic photoacoustic imaging by doing multispectral measurements on retinal pigment epithelium and blood samples with 15-nm linewidth.